Download ~ Ocular Surface Bacterial Colonisation in Sedated Intensive Care Unit Patients (Report) by Anaesthesia and Intensive Care ~ eBook PDF Kindle ePub Free
eBook details
- Title: Ocular Surface Bacterial Colonisation in Sedated Intensive Care Unit Patients (Report)
- Author : Anaesthesia and Intensive Care
- Release Date : January 01, 2010
- Genre: Health & Fitness,Books,Health, Mind & Body,
- Pages : * pages
- Size : 198 KB
Description
Prolonged eye closure, such as occurs in intensive care unit (ICU) patients, causes a cascade of biochemical, cellular and microbial events culminating in inflammation, hypoxia and dryeye states (1). Eyelid closure during sleep is an active process involving contraction and relaxation of eyelid muscles. This active contraction and relaxation is lost with the heavy sedation and use of muscle relaxants in ICU patients. The blink reflex is also lost. Incomplete lid closure leads to drying of the mucosal surface and desiccation of the corneal epithelial tissues, resulting in ulceration. Lesions can range from punctate epithelial erosions involving the exposed inferior third of the cornea to more extensive erosion termed macroepithelial defect. Disruption of the epithelial surface increases the risk of bacterial infection. The cornea is affected most often, with the most severe lesion being bacterial keratitis that may cause corneal opacity and blindness (2,3). Protective measures such as instillation of ocular lubricants (4,5) or masking the closed eye with tape and creating of a moisture chamber (6-8) do not seem to efficiently prevent keratitis in all sedated patients.
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